In this study, we…, Chronic kidney disease (CKD) is associated with accelerated atherosclerosis and increased mortality from cardiovascular disease. The new Molecular Devices instrument comes with a standard 1-year depot warranty service. D ... SpectraMax M2 & SpectraMax M2e Multi-mode Plate Readers User Guide — 0112-0102 Rev. They contain a wide range of high-performance capabilities ideal for life science research & drug discovery screening…, Molecular Devices is a leading provider of high-performance bioanalytical measurement solutions for life science research, pharmaceutical development, and biotherapeutic discovery. This video will give you the basics on setting up your Molecular Devices SpectraMax® M5e Microplate Reader to run Cisbio HTRF Assays. For example, a red cell-impermeant, DNA-binding dye only stains dead or dying cells whose membranes are compromised, while a green live-cell dye only fluoresces when metabolic enzymes are active. The Molecular Devices Spectramax M5e Multimode Microplate Reader offers you accuracy of a dedicated single mode reader across 5 modes of detection including being certified for Cisbio Bioassays HTRF technology. Plus; Plus384 * SpectraMax i3 Install Guide* SpectraMax i3* SpectraMax i3x* SpectraMax iD3* SpectraMax iD5* SpectraMax M-series Microplate readers. ©2021 Molecular Devices, LLC. Multi-Mode Microplate Readers. No. All rights reserved. Discover More: The ImageXpress ® Confocal HT.ai High-Content Imaging System combines premium hardware technology with IN Carta Image Analysis Software, a self-learning software analysis workflow for increased signal and ultra-fast 3D organoid screening. The SpectraMax® M5e Multi-Mode Microplate Reader from Molecular Devices delivers single-mode reader performance in one multi-mode reader package. Previous pharmacological studies found that baicalein had neuroprotective effects in animal models of Parkinson's disease. Providing our customers with innovative bioanalytical solutions for protein and cell biology for over 30 years. CRL-1658) Minimum Essential Medium (MEM, Corning Cat. Hyperhomocysteinemia increased lipid peroxidation and oxidative damage to protein, and disrupted antioxidant defenses (enzymatic and non-enzymatic) in the lung of rats, characterizing a reliable oxidative stress. SpectraNet is an intuitive, simple-to-use, self-service customer portal providing a new level of experience available 24/7. These proteins can be expressed in a diverse range of cells and organisms, where they are used to track many cellular processes, including protein synthesis and translocation, gene induction, and cell lineage. i3x) SpectraMax MiniMax 300 Imaging Cytometer (Molecular Devices Cat. Green fluorescent protein (GFP) from the jellyfish Aequorea victoria was the…, Cyclic nucleotide phosphodiesterases (PDEs) are a group of enzymes that degrade the phosphodiester bond of cAMP and cGMP, second messengers that are involved in a variety of biological…, HTRF is a versatile technology developed by Cisbio Bioassays for detecting biomolecular interactions1. We also provide information on common absorbance applications and assays including ELISAs, nucleic acid and protein quantitation, and microbial growth. Cell viability can be assessed by examining parameters such as cell membrane integrity or the activity of cellular enzymes. SpectraMax M2, M2e* SpectraMax M3, M4, M5, M5e* FilterMax™ Multi-Mode Detection Platform. To optimize signal detection, use solid white microplates rather than clear-bottom ones. No. SNP genotyping has proven very useful in identifying disease-related mutations in various species, and as a result many techniques for SNP detection have been developed. SpectraNet is an intuitive, simple-to-use, self-service customer portal providing a new level of experience available 24/7. View the Molecular Devices website Learn all about fluorescence detection – what it is, how it works, and the instruments used to measure the fluorescence of a sample. The Analyst®, FlexStation® and SpectraMax® M5/M5e from Molecular Devices have received the LanthaScreen® Certified designation from Invitrogen™ which ensures that these readers are validated to strict standards in instrument se Qualify Molecular Devices microplate readers in GLP or GMP environments with our IQ/OQ/PM Services to preserve the documentation of services in a compliant format that can be accessed remotely. SpectraMax L* SpectraMax Plus line. ©2021 Molecular Devices, LLC. 美谷分子仪器（上海）有限公司保留所有权利。 All Rights Reserved 沪ICP备05056171号-1, Baicalein is one of the major flavonoids obtained from the Scutellaria root. Wistar rats received daily subcutaneous injections of Hcy (0.3–0.6 μmol/g body weight) from the 6th to the 28th days-of-age and the control group received saline. On LabX buyers can find a variety of SpectraMAX models for sale: 190, 384, 340 and the SpectraMAX M series. COVID-19 RESPONSE - We are committed to supporting our scientific community during this pandemic. SpectraMax M5e Multi-Mode Microplate Reader. One of the…, Endpoint readers are prolific in the laboratory since absorbance has become the detection of choice for many applications. Molecular Devices is one of the leading provider of high-performance bioanalytical measurement solutions for life science research, pharmaceutical and biotherapeutic development. 美谷分子仪器（上海）有限公司保留所有权利。 All Rights Reserved 沪ICP备05056171号-1. for the SpectraMax Multi-Mode Microp late Reader, as well as all other Molecular Devices' microplate readers. Firstly, we investigated the effects of baicalein on rotenone-induced toxicity in PC12 cells. 3D-Culture, Organoids, & Organs-on-Chips 2021, Ananda Devices and Molecular Devices launch strategic collaboration to automate imaging and customize analysis of nervous system on-a-chip, Molecular Devices unveils next-generation imaging system with deep learning technology, Imaging system from Molecular Devices helps Recursion produce the largest publicly available set of human cellular morphological data for COVID-19 therapeutic research, Molecular Devices, LLC. Create your account today to get full access to integrated content and world-class customer service. Standard features include a cuvette port, spectral scanning in 1 nm increments, and up to six wavelengths per read. Learn about luminescence detection – what it is, how it works, and the advantages of luminescence over other detection modes. Molecular Devices The Analyst®, FlexStation® and SpectraMax® M5/M5 e from Molecular Devices have received the LanthaScreen® Certified designation from Life Technologies which ensures that these readers are validated to strict standards in instrument setup and assay performance. Tissue accumulation of homocysteine occurs in classical homocystinuria, a metabolic disease characterized biochemically by cystathionine β-synthase deficiency. The CyQUANT Cell Proliferation…, Fluorescent proteins have become enormously popular as tools for monitoring biological events in vivo. Previous pharmacological studies found that baicalein had neuroprotective effects in animal models of Parkinson's disease. Location: Belgium. The Molecular Devices SpectraMAX absorbance microplate readers mimic a dual beam spectrophotometer with a patented multichannel optical design. The Molecular Devices SpectraMax® M5/M5e Microplate Reader was tested for compatibility with Life Technologies Z’-LYTE ® Assay using the Z'-LYTE ® Tyr6 kit … Review date: 03 Jun 2011 ... SpectraMax® M5e Multi-Mode Microplate R... 5.000000 out of 5. Products : Gemini XPS reader, SpectraMax 190 reader, SpectraMax Plus 384 reader, SpectraMax M4 reader, SpectraMax M3 reader, SpectraMax M2/M2e reader, SpectraMax M5/M5e reader. Vascular manifestations such as myocardial infarction, cerebral thrombosis, hepatic steatosis, and pulmonary embolism are common in this disease and poorly understood. The optical system uses two scanning monochromators so you can determine optimal excitation and emission settings, resulting in assay performance similar to that of dedicated single-mode readers. In this…. Normal HDL confers protection against atherosclerosis by inhibiting the oxidation of lipids and lipoproteins and by retrieving surplus cholesterol and phospholipids from lipid-laden cells in the artery wall for disposal in the liver (reverse cholesterol transport). These results suggest that baicalein may be a mitochondria-targeted antioxidant and exerts neuroprotective effects on rotenone-induced neurotoxicity. Life sciences technology predictions for 2021, Molecular devices unveils next-generation imaging system with deep learning technology, Spectramax Glo Steady-Luc Reporter Assay Kit, Neurotransmitter Transporters Uptake Assay Kit, SpectraMax Injection cartridge with SmartInject Technology, Adjustable Petri Dish and Microplate Holder, CloneSelect Single-Cell Printer Cartridges, The ImageXpress ® Confocal HT.ai High-Content Imaging System. We’ll provide…. CKD results in oxidative stress, inflammation, and high-density lipoprotein (HDL) deficiency, which work in concert to promote atherosclerosis. Double-stranded DNA is typically quantitated in microplate readers by measuring the absorbance of the DNA solution at 260 nm. No. The Analyst®, FlexStation® and SpectraMax® M5/M5e from Molecular Devices have received the LanthaScreen® Certified designation from Invitrogen™ which ensures that these readers are validated to strict standards in instrument se Our findings showed a consistent profile of oxidative stress in the lung of rats, elicited by homocysteine, which could explain, at least in part, the mechanisms involved in the lung damage that is present in some homocystinuric patients. • SpectraMax M5e Multi-Mode Microplate Reader (Molecular Devices) Note: Always use white microplates when performing HTRF assays on the SpectraMax M5e reader. Examples include ELISAs for quantitation of cytokines and…, Quantitation of cell proliferation using fluorescence allows one to easily monitor the effects of drugs and other experimental treatments on cell growth. No. 5024062) NIH3T3 cells (ATCC Cat. The SpectraMax M5e Multi-Mode Microplate Reader features a triple-mode cuvette port, temperature control, microplate shaking, and the industry leading SoftMax Pro. Furthermore, we used isolated rat brain mitochondria to evaluate the effect of baicalein. All stand-alone instrument functions can be controlled using the software. With optimized reagents, validation tools, and industry-leading SoftMax® Pro Software, they provide consistent performance. On a microplate readers, these parameters can be detected using fluorescent reagents. SpectraMax i3x Multi-Mode Microplate Reader (Molecular Devices Cat. However, this method is only able to measure down to about 250…. We also cover many fluorescence-based assays including cell viability, GPCR activity, and fluorescent nucleic acid quantification. The trademarks mentioned herein are the property of Molecular Devices, Inc. or their respective owners. MicroplateReader,SpectraMax®M5Multi-ModeMicroplateReader,andSpectraMax®M5e Multi-ModeMicroplateReaderaredualmonochromator,multi-detectioninstrumentswith atriple-modecuvetteportanda6-wellto384-wellplatereadcapability. We use cookies to personalize content and improve your browsing experience. HTRF assays from Cisbio have evolved to encompass the areas of G protein-coupled receptors, kinases and cell signaling, epigenetics, and biomarkers. 3D-Culture, Organoids, & Organs-on-Chips 2021, Ananda Devices and Molecular Devices launch strategic collaboration to automate imaging and customize analysis of nervous system on-a-chip, Molecular Devices unveils next-generation imaging system with deep learning technology, Imaging system from Molecular Devices helps Recursion produce the largest publicly available set of human cellular morphological data for COVID-19 therapeutic research, Molecular Devices, LLC. D. SpectraMax M2 & SpectraMax M2e Multi-mode Plate Readers User Guide — 0112-0102 Rev. Fluorescent proteins have become enormously popular as tools for monitoring biological events in vivo. The many methods available for genotyping enable researchers to…, Measuring several different signal outputs simultaneously over time is especially useful for studying a protein or compound’s effect on cellular growth or gene expression. SoftMax Pro GxP Software extends data acquisition and analysis solution into regulated laboratories working under GMP, GLP, and 21 CFR Part 11 for secure electronic records. In recent years they have emerged as one of the most important classes of drug targets for cancer and many…, Cell viability assays are often performed to assess the effects of a variety of treatments, including drug candidates, pathway activators and inhibitors, and reporter genes. Sunnyvale, CA - May 17, 2011 - Today, Molecular Devices, a leading provider of instruments, software, and consumables for drug discovery and life sciences research, announced that NanoRacks, LLC has chosen the SpectraMax® …